The LIGHT impact case studies showcase how research can contribute to real-world change, beyond academia, when it is embedded within strong partnerships, meaningful stakeholder engagement, and a clear focus on evidence use. From influencing policy and practice to strengthening local capacity and partnerships, these case studies demonstrate how LIGHT supported more equitable, gender-responsive approaches to TB.  Across LIGHT countries and in different contexts, these case studies highlight what LIGHT did to address challenges, what changed (i.e., impact), and why it matters, offering practical lessons and recommendations for researchers, policymakers, and partners working to achieve real-world impact.